Reactions of organocuprates (Gilman Reagents)
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
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11-10-2020
2584
Reactions of organocuprates (Gilman Reagents)
Preparation of Gilman reagents
The Gilman reagent is a lithium diorganocopper species that can be prepared from organolithium compounds:
Coupling reactions of Gilman reagents with alkyl and acyl halides
Gilman reagents are useful in that, unlike Grignard reagents, they will efficiently react in SN2 reactions with alkyl halides, even when the halogen is bonded to an sp2-hybridized, alkene carbon .
In general, we see:
Exercises
- Starting with alkyl halides containing no more than four carbon atoms, how would you synthesize each of the following alkanes?
- 2,5-dimethylhexane
- 2-methylhexane
Answers
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