Synthesis of hemoglobin begins in the proerythroblasts and continues even into the reticulocyte stage of the RBCs. Therefore, when reticulocytes leave the bone marrow and pass into the blood stream, they continue to form minute quantities of hemoglobin for another day or so until they become mature erythrocytes.

Figure 1 shows the basic chemical steps in the formation of hemoglobin. First, succinyl-CoA, which is formed in the Krebs metabolic cycle, binds with glycine to form a pyrrole molecule. In turn, four pyrroles combine to form protoporphyrin IX, which then combines with iron to form the heme molecule. Finally, each heme molecule combines with a long polypeptide chain, a globin synthesized by ribosomes, forming a subunit of hemoglobin called a hemoglobin chain (Figure 2). Each chain has a molecular weight of about 16,000; four of these chains in turn bind together loosely to form the whole hemoglobin molecule.

Fig1. Formation of hemoglobin. 

Fig2. Basic structure of the heme moiety, showing one of  the four heme chains that bind together, along with globin polypeptide, to form the hemoglobin molecule. 

There are several slight variations in the different subunit hemoglobin chains, depending on the amino acid composition of the polypeptide portion. The different types of chains are designated alpha chains, beta chains, gamma chains, and delta chains. The most common form of hemoglobin in the adult human being, hemoglobin A, is a combination of two alpha chains and two beta chains. Hemoglobin A has a molecular weight of 64,458.

Because each hemoglobin chain has a heme prosthetic group containing an atom of iron, and because there are four hemoglobin chains in each hemoglobin molecule, one finds four iron atoms in each hemoglobin molecule; each of these can bind loosely with one molecule of oxygen, making a total of four molecules of oxygen (or eight oxygen atoms) that can be transported by each hemoglobin molecule.

The types of hemoglobin chains in the hemoglobin molecule determine the binding affinity of the hemoglobin for oxygen. Abnormalities of the chains can alter the physical characteristics of the hemoglobin molecule as well. For instance, in sickle cell anemia, the amino acid valine is substituted for glutamic acid at one point in each of the two beta chains. When this type of hemoglobin is exposed to low oxygen, it forms elongated crystals inside the RBCs that are sometimes 15 micrometers in length. These crystals make it almost impossible for the cells to pass through many small capillaries, and the spiked ends of the crystals are likely to rupture the cell membranes, leading to sickle cell anemia.

Hemoglobin Combines Reversibly With Oxygen. The most important feature of the hemoglobin molecule is its ability to combine loosely and reversibly with oxygen. This ability is discussed in detail in Chapter 41 in relation to respiration because the primary function of hemoglobin in the body is to combine with oxygen in the lungs and then to release this oxygen readily in the peripheral tissue capillaries, where the gaseous tension of oxygen is much lower than in the lungs.

Oxygen does not combine with the two positive bonds of the iron in the hemoglobin molecule. Instead, it binds loosely with one of the socalled coordination bonds of the iron atom. This bond is extremely loose, so the com bination is easily reversible. Furthermore, the oxygen does not become ionic oxygen but is carried as molecular oxygen (composed of two oxygen atoms) to the tissues, where, because of the loose, readily reversible combination, it is released into the tissue fluids still in the form of molecular oxygen rather than ionic oxygen.

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مواضيع ذات صلة

Erythropoietin Regulates Red Blood Cell Production

Stages of Differentiation of Red Blood Cells

Genesis of Blood Cells

Role of the Nervous System in Rapid Control of Arterial Pressure

Special Features of Nervous Control of Arterial Pressure

The Lymphatic System Plays A Key Role in Controlling Interstitial Fluid Protein Concentration, Volume, and Pressure

Formation of Lymph

Rate of Lymph Flow

Exchange of Water, Nutrients, and Other Substances Between the Blood and Interstitial Fluid

Flow of Blood in the Capillaries—Vasomotion

Structure of the Microcirculation and Capillary System

Basic Principles of Circulatory Function