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Biosynthesis of Triacylglycerols:- Eukaryotes Synthesize Anionic Phospholipids from CDP-Diacylglycerol

المؤلف:  David L. Nelson، Michael M. Cox

المصدر:  Lehninger Principles of Biochemistry

الجزء والصفحة:  811

2026-07-01

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Biosynthesis of Triacylglycerols:- Eukaryotes Synthesize Anionic Phospholipids from CDP-Diacylglycerol

In eukaryotes, phosphatidylglycerol, cardiolipin, and the phosphatidylinositols (all anionic phospholipids; see Fig. 10–8) are synthesized by the same strategy used for phospholipid synthesis in bacteria. Phosphatidylglycerol is made exactly as in bacteria. Cardiolipin synthesis in eukaryotes differs slightly: phosphatidylglycerol condenses with CDP-diacylglycerol (Fig. 21–26), not another molecule of phosphatidylglycerol as in E. coli (Fig.21–25). Phosphatidylinositol is synthesized by condensation of CDP-diacylglycerol with inositol (Fig. 21–26). Specific phosphatidylinositol kinases then convert phosphatidylinositol to its phosphorylated derivatives (see Fig. 10–17). Phosphatidylinositol and its phosphorylated products in the plasma membrane play a central role in signal transduction in eukaryotes (see Figs 12–8, 12–19).