تسجيل الدخول

تسجيل

Purified Protein Vaccines

المؤلف:  Peter Chin-Hong, Elizabeth A. Joyce, Manjiree Karandikar, Mehrdad Matloubian, Luis Alberto Rubio, Brian S. Schwartz, Warren Levinson

المصدر:  Levinsons Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases (2024)

الجزء والصفحة:  18th E , P89-90

2026-09-26

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(1) There are two types of Bordetella pertussis vaccines: an acellular vaccine containing purified proteins and a vaccine containing whole killed bacteria. The acellular vaccine is now recommended in the United States. The principal antigen in the acellular vaccine is inactivated pertussis toxin (pertussis toxoid), but other proteins, such as filamentous hemagglutinin and pertactin, are also required for full protection. Pertussis toxin for the vaccine is inactivated genetically by introducing two amino acid changes that eliminate its toxic (ADP-ribosylating) activity but retain its antigenicity. It is the first vaccine to contain a genetically inactivated toxoid. The vaccine is indicated for every child as a protection against whooping cough. It is usually given in combination with diphtheria and tetanus toxoids (DTP or DTaP vaccine).

(2) Bacillus anthracis vaccine contains “protective antigen” purified from the organism. It is given to persons whose occupations place them at risk of exposure to the organism.

(3) As mentioned above, challenges developing a polysaccharide-based vaccine for N. meningitidis serogroup B were overcome with the introduction of vaccines containing multiple surface-exposed proteins expressed by N. meningitidis serotype B. Factor H binding protein is the main antigen in these vac cines against serogroup B meningococci.