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Pharmacology of drugs in saliva , Methadone

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  176

2026-10-08

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Pharmacology of drugs in saliva

Methadone

Lynn et al. (1975) and DiGregorio et al. (1977a, b) reported that methadone is found in saliva after parenteral administration of methadone. Kang and Abbott (1982) reported a GC-MS method for methadone and 3-ethylidene 1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in saliva. The relative metabolic profile for methadone in blood, saliva, urine, sweat and hair is shown in Fig. 6.10. Wolff et al. (1991) found that saliva methadone concentrations could be used to estimate plasma methadone concentrations to monitor consumption of methadone. Since methadone has a pKa of 8.2, the saliva: plasma ratio is a function of saliva pH. Bermejo et al. (2000) reported that the methadone saliva: plasma ratio as a function of saliva pH ranged from 0.6 to 7.2 with an average of 3.7 (n 10) over a measured saliva pH range of 5.0–7.0. In the same specimens, the saliva: plasma ratio of EDDP ranged from 0.2 to 1.8 with an average of 0.89, and was not a function of saliva pH. Malcolm and Oliver (1997) reported that the saliva: wholebloodratiorangedfrom0.45to3.4.