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Date: 11-12-2019
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These differences above all point to internal salt formation by a proton transfer from the acidic carboxyl function to the basic amino group. The resulting ammonium carboxylate structure, commonly referred to as a zwitterion, is also supported by the spectroscopic characteristics of alanine.
CH3CH(NH2)CO2H | CH3CH(NH3)(+)CO2(–) |
As expected from its ionic character, the alanine zwitterion is high melting, insoluble in nonpolar solvents and has the acid strength of a 1º-ammonium ion. Examples of a few specific amino acids may also be viewed in their favored neutral zwitterionic form. Note that in lysine the amine function farthest from the carboxyl group is more basic than the alpha-amine. Consequently, the positively charged ammonium moiety formed at the chain terminus is attracted to the negative carboxylate, resulting in a coiled conformation.
The structure of an amino acid allows it to act as both an acid and a base. An amino acid has this ability because at a certain pH value (different for each amino acid) nearly all the amino acid molecules exist as zwitterions. If acid is added to a solution containing the zwitterion, the carboxylate group captures a hydrogen (H+) ion, and the amino acid becomes positively charged. If base is added, ion removal of the H+ ion from the amino group of the zwitterion produces a negatively charged amino acid. In both circumstances, the amino acid acts to maintain the pH of the system—that is, to remove the added acid (H+) or base (OH−) from solution.
Example 1.1
SOLUTION
The base removes H+ from the protonated amine group.
The acid adds H+ to the carboxylate group.
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إجراء أول اختبار لدواء "ثوري" يتصدى لعدة أنواع من السرطان
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دراسة تكشف "سببا غريبا" يعيق نمو الطيور
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قسم الشؤون الفكرية يقيم برنامج (صنّاع المحتوى الهادف) لوفدٍ من محافظة ذي قار
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الهيأة العليا لإحياء التراث تنظّم ورشة عن تحقيق المخطوطات الناقصة
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قسم شؤون المعارف يقيم ندوة علمية حول دور الجنوب في حركة الجهاد ضد الإنكليز
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وفد جامعة الكفيل يزور دار المسنين في النجف الأشرف
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